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KMID : 0606920100180010024
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Biomolecules & Therapeutics
2010 Volume.18 No. 1 p.24 ~ p.31
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Neuroprotective Effect of Taurine against Oxidative Stress-Induced Damages in Neuronal Cells
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Yeon Jeong-Ah
Kim Sung-Jin
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Abstract
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Taurine, 2-aminoethanesulfonic acid, is an abundant free amino acid present in brain cells and exerts many important biological functions such as anti-convulsant, modulation of neuronal excitability, regulation of learning and memory, anti-aggressiveness and anti-alcoholic effects. In the present study, we investigated to explore whether taurine has any protective actions against oxidative stress-induced damages in neuronal cells. ERK I/II regulates signaling pathways involved in nitric oxide (NO) and reactive oxygen species (ROS) production and plays a role in the regulation of cell growth, and apoptosis. We have found that taurine significantly inhibited AMPA induced cortical depolarization in the Grease Gap assays using rat cortical slices. Taurine also inhibited AMPA-induced neuronal cell damage in MTT assays in the differentiated SH-SY5Y cells. When the neuronal cells were treated with H2O2, levels of NO were increased; however, taurine pretreatment decreased the NO production induced by H2O2 to approximately normal levels. Interestingly, taurine treatment stimulated ERK I/II activity in the presence of AMPA or H2O2, suggesting the potential role of ERK I/II in the neuroprotection of taurine. Taken together, taurine has significant neuroprotective actions against AMPA or H2O2 induced damages in neuronal cells, possibly via activation of ERK I/II.
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KEYWORD
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Oxidative stress, AMPA, ERK I/II, Taurine, Neuronal cells
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